Clube Desportivo Santa Clara is a Portuguese football club from Ponta Delgada, Azores. They play in the 13,277-seat Estádio de São Miguel that is eligible for UEFA Champions League and Europa League games. They are the most successful football team from the Azores islands and the only team from the archipelago to compete in one UEFA competition: the Intertoto Cup. To date, Santa Clara is the only club from the Azores islands to have competed in the top division of the Portuguese Liga, being thus the westernmost top-flight club in Europe. They compete in the Primeira Liga, the Portuguese first division football league. Santa Clara's kit manufacturer is Adidas and their main sponsors are Banif and Açoreana Seguros. Main rivals are CD Operário from Lagoa. Other major rivals are C.S. Marítimo and C.D. Nacional, from the island of Madeira.

The Santa Clara Broncos men's basketball team represents Santa Clara University in NCAA Division I basketball competition. The team plays home games at the Leavey Center in Santa Clara, California and have been members of the West Coast Conference since its formation in 1952. The team is currently coached by Herb Sendek, who had previously been the head coach at NC State and Arizona State. Sendek was hired on March 29, 2016 Santa Clara has a long history of basketball success, having appeared in 11 NCAA Tournaments and 4 National Invitational Tournaments and producing a number of both collegiate All-Americans and NBA players. Recently, The 2010–11 team won the 2011 CollegeInsider.com Tournament and the 2012–13 team won the 2013 College Basketball Invitational. They are currently the only team to have won a CBI and a CIT.